Publications

2016

Chater-Diehl, EJ., Laufer, BI., Castellani, CA., Alberry, BL., Singh, SM. Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure. PLOS ONE[PDF] [Pubmed]

2015

Laufer, BI., and Singh, SM. Strategies for precision modulation of gene expression by epigenome editing: An overview. Epigenetics & Chromatin. [PDF] [Pubmed] [EpiGenie] [EpiBeat]

Laufer, BI., Kapalanga, J., Castellani, CA., Diehl, EJ., Yan, L., and Singh, SM. Associative DNA methylation changes in children with prenatal alcohol exposure. Epigenomics. [PDF] [Pubmed] [EpiGenie] [EpiBeat]

Castellani, CA.,  Laufer, BI., Melka, MG., Diehl, EJ., O’Reilly, R., and Singh, SM. DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks. BMC Medical Genomics. [PDF] [Pubmed] [EpiGenie]

Castellani*, CA., Melka*, MG., Diehl, EJ., Laufer, BI.,  O’Reilly, R., and Singh, SM. (2015) DNA methylation in psychosis: insights into etiology and treatment. Epigenomics. [PDF] [Pubmed]

2014

Kleiber, ML., Laufer, BI., Stringer, R., and Singh, SM. (2014) Third Trimester-Equivalent Ethanol Exposure Is Characterized by an Acute Cellular Stress Response and an Ontogenetic Disruption of Genes Critical for Synaptic Establishment and Function in Mice. Developmental Neuroscience. [PDF] [Pubmed]

Singh, SM., Laufer, BI., and Kapalanga, J. (2014) Fetal alcohol and the right to be born healthy…. Frontiers in Genetics. [PDF] [Pubmed]

Kleiber, ML., Diehl, EJ., Laufer, BI., Mantha, K., Chokroborty-Hoque, A., Alberry, B., and Singh, SM. (2014) Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: a model for fetal alcohol spectrum disorders. Frontiers in Genetics. [PDF] [Pubmed]

Mantha, K.,  Laufer, BI., and Singh, SM. (2014). Molecular changes during neurodevelopment following second-trimester binge ethanol exposure in a mouse model of fetal alcohol spectrum disorder: from immediate effects to long-term adaptation. Developmental Neuroscience. [PDF] [Pubmed]

Melka, MG., Laufer, BI., Castellani, CA.  Rajakumar, RN., O’Reilly, R., and Singh, SM. (2014) The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum. Clinical Epigenetics[PDF] [Pubmed] [EpiGenie]

2013

Laufer, BI., Mantha, K., Kleiber, ML., Diehl, EJ., Addison, SMF., and Singh, SM. (2013). Long lasting alterations to DNA methylation and ncRNAs may underlie the effects of fetal alcohol exposure. Disease Models & Mechanisms.  [PDF] [Pubmed] [Editorial Highlight] [EpiGenie] [Medical Xpress] [Qiagen] [Webinar]

Laufer, BI., Diehl, EJ., and Singh, SM. (2013).  Neurodevelopmental epigenetic etiologies: insights from studies on mouse models of fetal alcohol spectrum disorders. Epigenomics. [PDF] [Pubmed]

Stringer, R., Laufer, BI., Kleiber, M., and Singh, SM. Reduced expression of brain cannabinoid receptor 1 (Cnr1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders. (2013) Clinical Epigenetics. [PDF] [Pubmed]

Melka, MG.,  Castellani, CA. Laufer, BI., Rajakumar, RN., O’Reilly, R., and Singh, SM. (2013) Olanzapine induced DNA methylation changes support the dopamine hypothesis of psychosis. Journal of Molecular Psychiatry. [PDF] [Pubmed]

Anderson-Schmidt H, Beltcheva O, Brandon MD, Byrne EM, Diehl EJ, Duncan L, Gonzalez SD, Hannon E, Kantojarvi K, Karagiannidis I, Kos MZ, Kotyuk E, Laufer BI., Mantha K, McGregor NW, Meier S, Nieratschker V, Spiers H, Squassina A, Thakur GA, Tiwari Y, Viswanath B, Way MJ, Wong CCP, O’Shea A, DeLisi LE. (2013). Selected Rapporteur Summaries From the XX World Congress of Psychiatric Genetics, Hamburg, Germany, October 14–18, 2012. American Journal of Medical Genetics Part B. [PDF] [Pubmed]

2012

Laufer, BI., and Singh, S.M. (2012). A Macro Role for Imprinted Clusters of MicroRNAs in the Brain. MicroRNA. [PDF] [Pubmed]

Kleiber, ML., Laufer, BI., Wright, E., Diehl, EJ., and Singh, SM(2012). Long-term alterations to the brain transcriptome in a maternal voluntary consumption model of fetal alcohol spectrum disorders. Brain Research. [PDF] [Pubmed]

Conference Presentations

Laufer, BI., Kapalanga J, Diehl, EJ., Kleiber, ML., Chokroborty-Hoque, A., Alberry BLJ., Mantha, K., and Singh, SM. A Neuroepigenomic Model of the Fetal Alcohol Exposure Spectrum.  American Society of Human Genetics (ASHG). 18 October, 2014, San Diego, California, USA. Invited Poster Presentation. [Poster]

Laufer BI, Kapalanga J, Diehl EJ, Mantha K, Kleiber ML, Chokroborty-Hoque A, Alberry BLJ, Koren G, Singh SM. Translating epigenetic alterations in a mouse model to humans. The Fetal Alcohol Canadian Expertise (FACE) Research Association. September 7, 2013, St. John’s, Newfoundland and Labrador, Canada. First Place Invited Poster Presentation. [Poster]

Laufer, BI., Mantha, K., Kleiber, ML., Diehl, EJ., Addisson, SMF., and Singh, SM. Alterations in genomically imprinted miRNA and snoRNA clusters in a mouse model of Fetal Alcohol Spectrum Disorders (FASD).  American Society of Human Genetics (ASHG). 9 November, 2012, San Francisco, California, USA. Invited Oral Presentation. [Slides]

Laufer, BI., Mantha, K., Kleiber, ML., Diehl, EJ., Addisson, SMF., and Singh, SM. Alterations in genomically imprinted miRNA and snoRNA clusters in a mouse model of Fetal Alcohol Spectrum Disorders (FASD). World Conference of Psychiatric Genetics (WCPG). 15 October, 2012, Hamburg, Germany. Finalist in Invited Poster Presentations. [Poster]

Laufer, BI., Mantha, K., Kleiber, ML., Diehl, EJ., Addisson, SMF., and Singh, SM. Alterations in genomically imprinted miRNA and snoRNA clusters in a mouse model of Fetal Alcohol Spectrum Disorders (FASD). Mouse Molecular Genetics Conference. 4 October, 2012, Pacific Grove, California, USA. Invited Oral Presentation. [Slides]

Laufer, BI. Epigenetics: The Bridge Between Nature and Nurture. Western Research Forum. 27 March, 2012, London, Canada. Invited Oral Presentation.

Laufer, BI., Diehl, E., Kleiber, M., Janus, K., Wright, E., and Singh, S. Disruption of Imprinted Regions in a Mouse Model of Fetal Alcohol Spectrum Disorders (FASD). Biology Graduate Research Forum. 22 October, 2011, London, Canada. First Place Invited Oral Presentation. [Slides]

Laufer, BI., Diehl, E., Kleiber, M., Janus, K., Wright, E., and Singh, S. Disruption of Imprinted Regions in a Mouse Model of Fetal Alcohol Spectrum Disorders (FASD). 12th International Congress on Human Genetics and the 61st Annual Meeting of the American Society of Human Genetics. 11-15 October, 2011, Montreal, Canada. Invited Poster Presentation. [Poster]

Invited Peer Review Experience:

Translational Psychiatry (NPG)

Brain, Behaviour, and Immunity (Elsevier)

Media Coverage & Public Outreach:

QIAGEN’s Ingenuity Systems

University Affairs

Germline Exposures

EpiGenie

MedicalXpress

BioMed Central 

Technology.org

Western News

BC Adoption

EpiBeat

Scientific Communities (Past and Present): 

American Society of Human Genetics (ASHG)

Genetics Society of America (GSA)

The International Society of Psychiatric Genetics (ICPG)

Fetal Alcohol Canadian Expertise (FACE)

Webinar:

[Slides]

 

Advertisements